Tumour imaging by the detection of fibrin clots in tumour stroma using an anti-fibrin Fab fragment

Tumour imaging by the detection of fibrin clots in tumour stroma using an anti-fibrin Fab fragment

The diagnosis of early and aggressive types of cancer is important for providing effective cancer therapy. Cancer-induced fibrin clots exist only within lesions. Previously, we developed a monoclonal antibody (clone 102-10) that recognizes insoluble fibrin but not fibrinogen or soluble fibrin and confirmed that fibrin clots form continuously in various cancers. Here, we describe the development...

Dynamic changes of fibrin architecture during fibrin formation and intrinsic fibrinolysis of fibrin-rich clots.

Clotting and fibrinolysis are initiated simultaneously in vivo, and fibrinolysis usually occurs without any individualized lysis front (intrinsic fibrinolysis). We have developed a novel model to assess whether morphological changes resulting from intrinsic fibrinolysis are similar to those previously reported at the lysis front using externally applied lytic agents. Fibrin assembly and fibrino...

An Insight into the Abnormal Fibrin Clots — Its Pathophysiological Roles

Incorporation of thrombospondin into fibrin clots.

Thrombospondin is a major platelet glycoprotein which is released from platelets during blood coagulation. We examined the interaction of thrombospondin with polymerizing fibrin. Thrombospondin, purified from human platelets and labeled with 125I, became incorporated into clots formed from both plasma and purified fibrinogen. Plasma clots contained somewhat less thrombospondin than clots formed...

Structure and mechanics of fibrin clots formed under mechanical perturbation.

darone withdrawal can lead to under-anticoagulation, and therefore to an increased risk of thrombosis. In conclusion, we describe the first case of genetic VKA resistance in a child who had the p.Asp36Tyr mutation combined with g. 1185G>A and g. 679A>G mutations in the 5′-flanking region. VKA resistance was partially masked initially by concomitant amiodarone therapy. Both warfarin–drug interac...